SOUTH AFRICA RESEARCH CONSORTIA
UNIVERSITY OF CAPE TOWN (UCT)-BOSTON UNIVERSITY MEDICAL CENTER
Title: The Clinical Research Unit (CRU) for Advancement of Tuberculosis (TB) Biomarker-Targeted Interventions
Participating Patient Cohorts:
Participants with Active Pulmonary TB – University of Pretoria, (Cohort A)
Participants who are Household contacts (HHCs) to an active case of TB – Stellenbosch University, (Cohort B)
Principal Investigators:
Dr. Mark Hatherill, South African Tuberculosis Vaccine Initiative (SATVI), Cape Town
Dr. Jerrold Ellner, Boston University Medical Center, Boston
Prof Gerhard Walzl, Stellenbosch University
Prof Bernard Fourie University of Pretoria
WITS HEATH CONSORTIUM-JOHNS HOPKINS UNIVERSITY
Title: TB in hot and cold spots in South Africa: researching index cases and their households
Participating Patient Cohorts:
Participants with Active Pulmonary TB (Cohort A)
Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)
Principal Investigators:
Dr. Neil Alexander Martinson, Perinatal HIV Research Unit (PHRU)-WHC, Chris Hani Baragwanath Hospital, Soweto
Dr. Richard E. Chaisson, John Hopkins University, Baltimore
UNIVERSITY OF CAPE TOWN (UCT) - BAYLOR COLLEGE OF MEDICINE
Title: Highly sensitive cartridge-based nucleic acid amplification testing for the diagnosis of pulmonary tuberculosis in children
Participating Patient Cohorts:
Participants with Active Pulmonary TB (Cohort A)
Principal Investigators:
Dr. Mark Nicol, University of Cape Town, Cape Town
Dr. Heather Zar, Red Cross Children's Hospital, Cape Town
Dr. Jeffrey Starke, Baylor College of Medicine, Texas
UNIVERSITY OF CAPE TOWN (UCT)-BAYLOR RESEARCH INSTITUTE
Title: Quantifying infectiousness of undiagnosed tuberculosis cases and impact of enhanced community-based active case finding strategy using novel diagnostic tools – a randomized controlled trial
Participating Patient Cohorts:
Participants with Active Pulmonary TB (Cohort A)
Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)
Principal Investigators:
Dr. Keertan Dheda, University of Cape Town, Cape Town
Dr. Tawanda Gumbo, Baylor Research Institute, Texas
KWAZULU-NATAL RESEARCH INSTITUTE for TB and HIV (K-RITH) dba AFRICA HEALTH RESEARCH INSTITUTE (AHRI)-VANDERBILT UNIVERSITY
Title: Identifying Innovative Bacterial and Host-Mediated Biomarkers of Treatment Response to Tuberculosis Chemotherapy
Participating Patient Cohorts:
Participants with Active Pulmonary TB (Cohort A)
Principal Investigators:
Dr. Al Leslie, AHRI, Durban
PERINATAL HIV RESEARCH UNIT-WITS HEALTH CONSORTIUM
Title: Enhancing diagnostics and improving outcomes in childhood Tuberculosis (EDICT Study)
Participating Patient Cohorts:
Participants with Active Pulmonary TB (Cohort A)
Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)
Principal Investigators:
Dr. Sanjay Lala, University of Witwatersrand
Chris Hani Baragwanath Academic Hospital