SOUTH AFRICA RESEARCH CONSORTIA

UNIVERSITY OF CAPE TOWN (UCT)-BOSTON UNIVERSITY MEDICAL CENTER

 

Title: The Clinical Research Unit (CRU) for Advancement of Tuberculosis (TB) Biomarker-Targeted Interventions

 

Participating Patient Cohorts: 

Participants with Active Pulmonary TB – University of Pretoria, (Cohort A)
Participants who are Household contacts (HHCs) to an active case of TB – Stellenbosch University, (Cohort B)

 

Principal Investigators:

Dr. Mark Hatherill, South African Tuberculosis Vaccine Initiative (SATVI), Cape Town
Dr. Jerrold Ellner, Boston University Medical Center, Boston
Prof Gerhard Walzl, Stellenbosch University
Prof Bernard Fourie University of Pretoria

WITS HEATH CONSORTIUM-JOHNS HOPKINS UNIVERSITY

 

Title: TB in hot and cold spots in South Africa: researching index cases and their households

 

Participating Patient Cohorts: 

Participants with Active Pulmonary TB (Cohort A) 
Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)
 

Principal Investigators:

Dr. Neil Alexander Martinson, Perinatal HIV Research Unit (PHRU)-WHC, Chris Hani Baragwanath Hospital, Soweto
Dr. Richard E. Chaisson, John Hopkins University, Baltimore

UNIVERSITY OF CAPE TOWN (UCT) - BAYLOR COLLEGE OF MEDICINE

 

Title: Highly sensitive cartridge-based nucleic acid amplification testing for the diagnosis of pulmonary tuberculosis in children

 

Participating Patient Cohorts: 

Participants with Active Pulmonary TB (Cohort A) 
 

Principal Investigators:

Dr. Mark Nicol, University of Cape Town, Cape Town
Dr. Heather Zar, Red Cross Children's Hospital, Cape Town
Dr. Jeffrey Starke, Baylor College of Medicine, Texas 

UNIVERSITY OF CAPE TOWN (UCT)-BAYLOR RESEARCH INSTITUTE

 

Title: Quantifying infectiousness of undiagnosed tuberculosis cases and impact of enhanced community-based active case finding strategy using novel diagnostic tools – a randomized controlled trial

 

Participating Patient Cohorts: 

Participants with Active Pulmonary TB (Cohort A) 
Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)
 

Principal Investigators:

Dr. Keertan Dheda, University of Cape Town, Cape Town
Dr. Tawanda Gumbo, Baylor Research Institute, Texas

KWAZULU-NATAL RESEARCH INSTITUTE for TB and HIV (K-RITH) dba AFRICA HEALTH RESEARCH INSTITUTE (AHRI)-VANDERBILT UNIVERSITY

 

Title: Identifying Innovative Bacterial and Host-Mediated Biomarkers of Treatment Response to Tuberculosis Chemotherapy

 

Participating Patient Cohorts: 

Participants with Active Pulmonary TB (Cohort A) 
 

Principal Investigators:

Dr. Al Leslie, AHRI, Durban

PERINATAL HIV RESEARCH UNIT-WITS HEALTH CONSORTIUM

 

Title: Enhancing diagnostics and improving outcomes in childhood Tuberculosis (EDICT Study)

 

Participating Patient Cohorts:

Participants with Active Pulmonary TB (Cohort A)
Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)
 

Principal Investigators:

Dr. Sanjay Lala, University of Witwatersrand
Chris Hani Baragwanath Academic Hospital

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