Progress in tuberculosis (TB) clinical research is hampered by a lack of reliable biomarkers that predict progression from latent to active TB, and subsequent cure, relapse, or failure. RePORT International consortia are linked through the implementation of a common protocol for data and specimen collection and are poised to address this critical research need. Each RePORT network is designed to support local, in-country TB-specific data, specimen biorepositories, and associated research. Taken together, the expected results include greater global clinical research capacity in high-burden settings and increased local access to quality data and specimens for members of each network and their domestic and international collaborators. Current RePORT projects are studying cohorts with active pulmonary TB disease as well as cohorts of household contacts to active TB cases. Populations being studied include adults and children, and individuals with and without important co-factors including HIV/AIDS and diabetes. It is hoped that the standardized approach to clinical and biological data collection will facilitate sharing of samples and linked data for biomarker and other translational research.