The purpose of Regional Prospective Observational Research for Tuberculosis (RePORT) International is to advance regional tuberculosis (TB) science that is also relevant in a global context; strengthen TB research capacity and infrastructure in high TB burden settings; and serve as an entity to foster research collaboration within each country and internationally, with the aim of carrying out a wide range of basic and clinical research that can lead to clinically important TB biomarkers, vaccines, drugs, and diagnostics.  Many of the RePORT consortia include explicit partnerships with U.S. TB scientists to facilitate capacity-building and cross-fertilization of ideas.