RePORT SA is a joint venture among the South African Medical Research Council (SAMRC), with support from the South African Department of Science and Technology (DST) and Department of Health (DOH), and with co-funding by the U.S. Division of AIDS (DAIDS), National Institute for Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH), and the Office of AIDS Research (OAR). In 2015 the SAMRC, as part of this initiative, established the SAMRC TB HIV Collaborating Centers, which exclusively competed through a request for application (RFA) process for a RePORT SA award. Five sites were awarded and investigators are funded to enroll subjects from their existing parent protocol with compliance to the RePORT International Common Protocol, in which eligible subjects from each parent protocol will be co-enrolled. Enrollment of active TB cases and latently TB infected (LTBI) household contacts of active TB cases in their parent protocols has started. RePORT SA also received two awards for Maternal Health and Pediatrics (RePORT Pediatrics).

 

The RePORT SA-affiliated sites are the South African Tuberculosis Vaccine Initiative (SATVI), the Centre for Tuberculosis Research Innovation (CTBRI), and the Clinical Infectious Disease Research Initiative (CIDRI) at the University of Cape Town; Stellenbosch University Immunology Research Group (SU-IRG), the MECRU research unit at Sefako Makgatho Health Sciences University (SMU); and the Nuclear Medicine facility and Mycobacteriology Research Laboratory of the University of Pretoria, in collaboration with U.S. partners at Boston Medical Center and Rutgers University, focusing on biomarker targeted interventions; Lung Infection and Immunity Unit at UCT Cape Town, with a U.S. partner from Baylor Research Institute, using a community-based active case-finding strategy to quantify infectiousness of undiagnosed TB cases and the impact thereof using novel diagnostic tools; Perinatal HIV Research Unit (PHRU-Johannesburg), with U.S. partners at John Hopkins University, recruiting from two sites in Limpopo Province, SA with high and low incidence of TB by researching index cases in adult and pediatric population and their household contacts; Africa Health Research Institute (AHRI) in Durban with a U.S. partner at Vanderbilt University, focuses on a prospective observational cohort of microbiologically confirmed TB patients initiating standard chemotherapy to evaluate novel biomarkers of treatment response; Research Centre on Child and Adolescent Health (REACH), Red Cross War Memorial Children’s Hospital, Cape Town (the core site) and Dora Nginza Hospital (Port Elizabeth) with U.S. partners at Baylor College, focuses on a pediatric cohort of HIV-infected children to develop improved diagnostic strategies for TB in children using microbiological and immunological strategies. Additionally, with the new RePORT pediatrics award, this site will optimize oral swab processing protocols for the Ultra assay and will evaluate the accuracy of oral swab Ultra for the diagnosis of PTB in HIV-infected and uninfected children presenting to hospital with suspected PTB. PHRU, through a new RePORT pediatrics award, will investigate enhancing diagnostics and improving outcomes in childhood TB. TB disease most commonly presents with features indistinguishable from acute bacterial or viral lower respiratory tract infections (LRTI) in this population.  Two site-specific studies will be undertaken: one determining if TB affected-children with nonreactive tuberculin skin tests (TST) are at risk of poorer nutritional outcomes following the completion of TB treatment and the second will determine whether hospital-based source case investigation (SCI) for TB disease and/or HIV infection should be urgently implemented for caregivers of children with TB and LRTI.

 

RePORT SA is supported by the SAMRC with a central bio-repository, situated in Durban and central data management center situated in Johannesburg. The biorepository and data management centers will work together to synchronize sample collection and data across the SA consortium.