Regional Prospective Observational Research in Tuberculosis (RePORT)
Tuberculosis (TB) remains one of the most significant infectious causes of mortality and
morbidity worldwide and is the number one cause of death among those infected with HIV.
Major research needs span from basic research to identify biomarkers that accurately
predict outcomes of active and latent TB to clinical research to measure efficacy and
effectiveness of new tools and strategies for TB. To meet this need, the National Institute of
Allergy and Infectious Diseases (NIAID) has created the Regional Prospective Observational
Research in Tuberculosis (RePORT) International program to support the establishment of
regional RePORT consortia in cooperation with host countries. This platform sets the stage
for future combined or comparative data analyses and is an invaluable resource for in-
country and cross-national collaborations between bench and clinical researchers.
Progress in TB clinical research is hampered by a lack of reliable biomarkers that predict
progression from latent to active tuberculosis, and subsequent cure, relapse, or failure.
RePORT International represents a consortium of regional cohorts (RePORT India, RePORT
Brazil, RePORT South Africa, RePORT Indonesia, and RePORT China, and RePORT
Philippines) that are linked through the implementation of a common protocol for data and
specimen collection and are poised to address this critical research need. Each RePORT
network is designed to support local, in-country TB-specific data and specimen
biorepositories and associated research. Taken together, the expected results include
greater global clinical research capacity in high-burden settings, and increased local access to quality data and specimens for members of each network and their domestic and
The mission of the Regional Prospective Observational Research for Tuberculosis (RePORT) International is to advance tuberculosis (TB) science globally, with emphasis on translational research to provide new tools for TB control. To do this RePORT International will promote harmonization of data across the RePORT consortia and development of TB research capacity and infrastructure.