Regional Prospective Observational Research in Tuberculosis (RePORT)

Tuberculosis (TB) remains one of the most significant infectious causes of mortality and morbidity worldwide and is the number one cause of death among those infected with HIV. Major research needs span from basic research to identify biomarkers that accurately predict outcomes of active and latent TB to clinical research to measure efficacy and effectiveness of new tools and strategies for TB. To meet this need, the National Institute of Allergy and Infectious Diseases (NIAID) has created the Regional Prospective Observational Research in Tuberculosis (RePORT) International program to support the establishment of regional RePORT consortia in cooperation with host countries.  This platform sets the stage for future combined or comparative data analyses and is an invaluable resource for in-country and cross-national collaborations between bench and clinical researchers.  


Progress in TB clinical research is hampered by a lack of reliable biomarkers that predict progression from latent to active tuberculosis, and subsequent cure, relapse, or failure. RePORT International represents a consortium of regional cohorts (RePORT India, RePORT Brazil, RePORT South Africa, RePORT Indonesia and RePORT China) that are linked through the implementation of a common protocol for data and specimen collection and are poised to address this critical research need. Each RePORT network is designed to support local, in-country TB-specific data and specimen biorepositories and associated research. Taken together, the expected results include greater global clinical research capacity in high-burden settings, and increased local access to quality data and specimens for members of each network and their domestic and international collaborators.