UNIVERSITY OF CAPE TOWN (UCT)-BOSTON UNIVERSITY MEDICAL CENTER
Title: The Clinical Research Unit (CRU) for Advancement of Tuberculosis (TB) Biomarker-Targeted Interventions
Participating Patient Cohorts:
- Participants with Active Pulmonary TB – University of Pretoria, (Cohort A)
- Participants who are Household contacts (HHCs) to an active case of TB – Stellenbosch University, (Cohort B)
Principal Investigators:
- Dr. Mark Hatherill, South African Tuberculosis Vaccine Initiative (SATVI), Cape Town
- Dr. Jerrold Ellner, Boston University Medical Center, Boston
- Prof Gerhard Walzl, Stellenbosch University
- Prof Bernard Fourie University of Pretoria
WITS HEATH CONSORTIUM-JOHNS HOPKINS UNIVERSITY
Title: TB in hot and cold spots in South Africa: researching index cases and their households
Participating Patient Cohorts:
- Participants with Active Pulmonary TB (Cohort A)
- Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)
Principal Investigators:
- Dr. Neil Alexander Martinson, Perinatal HIV Research Unit (PHRU)-WHC, Chris Hani Baragwanath Hospital, Soweto
- Dr. Richard E. Chaisson, John Hopkins University, Baltimore
UNIVERSITY OF CAPE TOWN (UCT) - BAYLOR COLLEGE OF MEDICINE
Title: Highly sensitive cartridge-based nucleic acid amplification testing for the diagnosis of pulmonary tuberculosis in children
Participating Patient Cohorts:
- Participants with Active Pulmonary TB (Cohort A)
Principal Investigators:
- Dr. Mark Nicol, University of Cape Town, Cape Town
- Dr. Heather Zar, Red Cross Children's Hospital, Cape Town
- Dr. Jeffrey Starke, Baylor College of Medicine, Texas
UNIVERSITY OF CAPE TOWN (UCT)-BAYLOR RESEARCH INSTITUTE
Title: Quantifying infectiousness of undiagnosed tuberculosis cases and impact of enhanced community-based active case finding strategy using novel diagnostic tools – a randomized controlled trial
Participating Patient Cohorts:
- Participants with Active Pulmonary TB (Cohort A)
- Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)
Principal Investigators:
- Dr. Keertan Dheda, University of Cape Town, Cape Town
- Dr. Tawanda Gumbo, Baylor Research Institute, Texas
KWAZULU-NATAL RESEARCH INSTITUTE for TB and HIV (K-RITH) dba AFRICA HEALTH RESEARCH INSTITUTE (AHRI)-VANDERBILT UNIVERSITY
Title: Identifying Innovative Bacterial and Host-Mediated Biomarkers of Treatment Response to Tuberculosis Chemotherapy
Participating Patient Cohorts:
- Participants with Active Pulmonary TB (Cohort A)
Principal Investigators:
- Dr. Alexander Pym, K-RITH dba AHRI, Durban
- Dr. Timothy Sterling, Vanderbilt University Medical Center, Nashville
PERINATAL HIV RESEARCH UNIT-WITS HEALTH CONSORTIUM
Title: Enhancing diagnostics and improving outcomes in childhood Tuberculosis (EDICT Study)
Participating Patient Cohorts:
- Participants with Active Pulmonary TB (Cohort A)
- Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)
Principal Investigators:
- Dr. Sanjay Lala, University of Witwatersrand
- Chris Hani Baragwanath Academic Hospital