UNIVERSITY OF CAPE TOWN (UCT)-BOSTON UNIVERSITY MEDICAL CENTER

 

Title: The Clinical Research Unit (CRU) for Advancement of Tuberculosis (TB) Biomarker-Targeted Interventions

 

Participating Patient Cohorts: 

  • Participants with Active Pulmonary TB – University of Pretoria, (Cohort A)
  • Participants who are Household contacts (HHCs) to an active case of TB – Stellenbosch University, (Cohort B)

 

Principal Investigators:

  • Dr. Mark Hatherill, South African Tuberculosis Vaccine Initiative (SATVI), Cape Town
  • Dr. Jerrold Ellner, Boston University Medical Center, Boston
  • Prof Gerhard Walzl, Stellenbosch University
  • Prof Bernard Fourie University of Pretoria

WITS HEATH CONSORTIUM-JOHNS HOPKINS UNIVERSITY

 

Title: TB in hot and cold spots in South Africa: researching index cases and their households

 

Participating Patient Cohorts: 

  • Participants with Active Pulmonary TB (Cohort A) 
  • Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)

 

Principal Investigators:

  • Dr. Neil Alexander Martinson, Perinatal HIV Research Unit (PHRU)-WHC, Chris Hani Baragwanath Hospital, Soweto
  • Dr. Richard E. Chaisson, John Hopkins University, Baltimore

 


UNIVERSITY OF CAPE TOWN (UCT) - BAYLOR COLLEGE OF MEDICINE

 

Title: Highly sensitive cartridge-based nucleic acid amplification testing for the diagnosis of pulmonary tuberculosis in children

 

Participating Patient Cohorts: 

  • Participants with Active Pulmonary TB (Cohort A) 

 

Principal Investigators:

  • Dr. Mark Nicol, University of Cape Town, Cape Town
  • Dr. Heather Zar, Red Cross Children's Hospital, Cape Town
  • Dr. Jeffrey Starke, Baylor College of Medicine, Texas 

 

UNIVERSITY OF CAPE TOWN (UCT)-BAYLOR RESEARCH INSTITUTE

 

Title: Quantifying infectiousness of undiagnosed tuberculosis cases and impact of enhanced community-based active case finding strategy using novel diagnostic tools – a randomized controlled trial

 

Participating Patient Cohorts: 

  • Participants with Active Pulmonary TB (Cohort A) 
  • Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)

 

Principal Investigators:

  • Dr. Keertan Dheda, University of Cape Town, Cape Town
  • Dr. Tawanda Gumbo, Baylor Research Institute, Texas

KWAZULU-NATAL RESEARCH INSTITUTE for TB and HIV (K-RITH) dba AFRICA HEALTH RESEARCH INSTITUTE (AHRI)-VANDERBILT UNIVERSITY

 

Title: Identifying Innovative Bacterial and Host-Mediated Biomarkers of Treatment Response to Tuberculosis Chemotherapy

 

Participating Patient Cohorts

  • Participants with Active Pulmonary TB (Cohort A) 

 

Principal Investigators:

  • Dr. Alexander Pym, K-RITH dba AHRI, Durban
  • Dr. Timothy Sterling, Vanderbilt University Medical Center, Nashville

 

PERINATAL HIV RESEARCH UNIT-WITS HEALTH CONSORTIUM

 

Title: Enhancing diagnostics and improving outcomes in childhood Tuberculosis (EDICT Study)

 

    Participating Patient Cohorts:

    • Participants with Active Pulmonary TB (Cohort A)
    • Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)

     

    Principal Investigators:

    • Dr. Sanjay Lala, University of Witwatersrand
    • Chris Hani Baragwanath Academic Hospital