UNIVERSITY OF CAPE TOWN (UCT)-BOSTON UNIVERSITY MEDICAL CENTER

Title: The Clinical Research Unit (CRU) for Advancement of Tuberculosis (TB) Biomarker-Targeted Interventions

Participating Patient Cohorts: 

• Participants with Active Pulmonary TB – University of Pretoria, (Cohort A)
• Participants who are Household contacts (HHCs) to an active case of TB – Stellenbosch University, (Cohort B)

Principal Investigators:

• Dr. Mark Hatherill, South African Tuberculosis Vaccine Initiative (SATVI), Cape Town
• Dr. Jerrold Ellner, Boston University Medical Center, Boston
• Prof Gerhard Walzl, Stellenbosch University
• Prof Bernard Fourie University of Pretoria

WITS HEATH CONSORTIUM-JOHNS HOPKINS UNIVERSITY

Title: TB in hot and cold spots in South Africa: researching index cases and their households

Participating Patient Cohorts: 

• Participants with Active Pulmonary TB (Cohort A) 
• Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)

Principal Investigators:

• Dr. Neil Alexander Martinson, Perinatal HIV Research Unit (PHRU)-WHC, Chris Hani Baragwanath Hospital, Soweto
• Dr. Richard E. Chaisson, John Hopkins University, Baltimore

UNIVERSITY OF CAPE TOWN (UCT) - BAYLOR COLLEGE OF MEDICINE

Title: Highly sensitive cartridge-based nucleic acid amplification testing for the diagnosis of pulmonary tuberculosis in children

Participating Patient Cohorts: 

• Participants with Active Pulmonary TB (Cohort A) 

Principal Investigators:

• Dr. Mark Nicol, University of Cape Town, Cape Town
• Dr. Heather Zar, Red Cross Children's Hospital, Cape Town
• Dr. Jeffrey Starke, Baylor College of Medicine, Texas 

UNIVERSITY OF CAPE TOWN (UCT)-BAYLOR RESEARCH INSTITUTE

Title: Quantifying infectiousness of undiagnosed tuberculosis cases and impact of enhanced community-based active case finding strategy using novel diagnostic tools – a randomized controlled trial

Participating Patient Cohorts: 

• Participants with Active Pulmonary TB (Cohort A) 
• Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)

Principal Investigators:

• Dr. Keertan Dheda, University of Cape Town, Cape Town
• Dr. Tawanda Gumbo, Baylor Research Institute, Texas

KWAZULU-NATAL RESEARCH INSTITUTE for TB and HIV (K-RITH) dba AFRICA HEALTH RESEARCH INSTITUTE (AHRI)-VANDERBILT UNIVERSITY

Title: Identifying Innovative Bacterial and Host-Mediated Biomarkers of Treatment Response to Tuberculosis Chemotherapy

Participating Patient Cohorts: 

• Participants with Active Pulmonary TB (Cohort A) 

Principal Investigators:

• Dr. Alexander Pym, K-RITH dba AHRI, Durban
• Dr. Timothy Sterling, Vanderbilt University Medical Center, Nashville

PERINATAL HIV RESEARCH UNIT-WITS HEALTH CONSORTIUM

Title: Enhancing diagnostics and improving outcomes in childhood Tuberculosis (EDICT Study)

Participating Patient Cohorts:

• Participants with Active Pulmonary TB (Cohort A)
• Participants who are Household contacts (HHCs) to an active case of TB (Cohort B)

Principal Investigators:

• Dr. Sanjay Lala, University of Witwatersrand
• Chris Hani Baragwanath Academic Hospital